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However, heterogeneous outcomes have been noticed in terms of T cell infiltration, suggesting a unique potential benefit after ICI therapies. It has been proposed that neoAg-specific T cells play a prominent role in ICI efficacy, since TMB correlates with the response fee to these therapies . Although TNBC has been described as a tumor with a mutational load greater than other breast tumors , it is well known that, just like tumor infiltrates, there’s a extensive spectrum of mutational burden between sufferers .

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Competitions chevron_rightInterviews chevron_right. Vaccines can induce tumor-specific T cells that might generate an enriched lymphocytic infiltrate, growing thus the possibility of responding to ICI. Infiltrating T cells have been present in TNBC sufferers .